Maqsudul Alam Bio, Born, Age, Death, Height, Facts, Family, News, Secrets, Trivia, Updates
- Name: Maqsudul Alam
- Date of Birth: December 14, 1954
- Age: 60 Years
- Place of Birth: Faridpur, East Bengal
- Profession: Scientist and Professor
- Nationality: Bangladeshi
- Alma Mater: Moscow State University, Max Planck Institute of Biochemistry
- Legend For: Jute Genome Decoding
- Date of Death: 20 December 2014
- Award: Independence Day award from Government of Bangladesh
Why Maqsudul Alam is Legend of Bangladesh?
Maqsudul Alam (14 December 1954 – 20 December 2014) was a Bangladeshi researcher, scientist, and professor. He accomplished four points of reference in genomics: sequencing the genomes of papaya, rubber, jute, and fungus. He was a professor of the University of Hawaii at Manoa and an individual from an advisory board at Shahjalal University of Science and Technology. He was granted Independence Day Award in 2016 after death by the Government of Bangladesh.
Family Background of Maqsudul Alam
Alam was conceived on Dec 14, 1954, in Faridpur. His dad, a hero of the 1971 Liberation War, was an authority of the then East Pakistan Rifles and mother Lyrian Ahmed a teacher.
Education Profile of Maqsudul Alam
He cleared out for Russia after independence and finished his post-graduate degree in microbiology in 1979 and a Ph.D. in 1982 from the Moscow State University. After five years, Alam finished his second doctorate in natural chemistry from Germany’s Max-Planck-Institute of Biochemistry.
Career as Analyst and Professor
Before joining the University of Hawaii, he functioned as an analyst and professor at the Moscow State University, the Academy of Sciences in Moscow, Max-Planck-Institute and Washington State University in the US.
He is died on 20 December, 2014 at the age of 60 cirrhosis of the liver. President Md Abdul Hamid and Prime Minister Sheik Hasina have communicated their sympathy over the demise of the researcher. Relatives said that Alam have been covered at the Hawaii Memorial Park Cemetery according to his last wishes.
Achievement of Finding out “Tosha” Jute
Dr. Alam and his group turned out to be famous all around acclaimed for finding the genome sequence of ‘Tosha’ jute, “the Jute Plant Draft Genome” in June 2010. Prime Minister Sheikh Hasina broke the news in the Parliament on Jun 16 that year. Their triumph proceeded as they sequenced the DNA make-up of a fungus, Macrophomina phaseolina, which diminishes yield of in excess of 500 species of crops including jute, soybean, cotton, tobacco, maize, and sunflower. In Aug a year ago, Prime Minister Sheik Hasina, flanked by Dr. Alam, declared that the group has sequenced the DNA of the conventional variety of jute called ‘Tosha’.
A genome is a life form’s entire arrangement of DNA, including every one of its genes. Every genome contains all the data expected to assemble and keep up that life form. The decoding empowers Bangladesh to claim all the hereditary archives of the normal fiber which has returned as a significant asset in the crusade for environment-friendly fibers.
Helping of Gene Sequencing to enhance Fiber length and Quality
Specialists say this gene sequencing will help enhance the fiber length and quality, including colors and quality; and grow high yielding, saline soil-and pest-safe jute assortments through genetic engineering.
Achievement as Sequencing the Genomes of Papaya in the US and Rubber in Malaysia
Dr. Alam, who instructed at the University of Hawaii at Manoa, has accomplished two more developments in genomics – sequencing the genomes of papaya in the US and rubber in Malaysia in 2008. He was the chief of the Genomics, Proteomics and Bioinformatics Department at the College of Natural Sciences.
Starting of Project of “Sequencing the Jute Genome”
Everything started in February 2008, when Maqsudul Alam moved toward Professor Ahmad Shamsul Islam, Coordinator of GNOBB (Global Network of Bangladeshi Biotechnologists) with respect to the likelihood of sequencing the jute genome. The Bangladeshi science group, which was at that point investigating the likelihood of getting the jute genome sequenced, reacted to this offer, which began the procedure. The entire procedure started with numerous long phone calls between Dr. Alam and plant molecular scientists, Professors Haseena Khan and Zeba Islam Seraj of the Department of Biochemistry and Molecular Biology, University of Dhaka.
Association between University of Hawaii, USA and University of Science Malaysia to Finance “Sequencing the Jute Genome” Project
They built up an association with University of Hawaii, USA and the University of Science Malaysia for specialized help and arranged a venture proposition to gather finance from various foundations. Toward the start, there was numerous affirmation yet the truth was unique.
Collection of Data about Jute from Around the World and Analyzing through Supercomputers
In the essential stage, Genome Research Center USA and the University of Science Malaysia gave some specialized help to gather look into information about jute from everywhere throughout the world. To analyze a gigantic measure of information, there emerged a requirement for a supercomputer. There was still need of financing for field look into. “Swapnajatra” group wind up baffled by not getting legitimate help. It wound up hard to keep drawing in the colleagues. In 2009, The Daily Prothom Alo distributed an article about the exploration that changed everything. Agriculture Minister Matia Chowdhury presented Dr. Maqsudul Alam to PM Sheik Hasina and guaranteed further help. In this way group, “Swapnajatra” recaptured their certainty and proceeded with their work.
Resources of Genome Jute
Genomic DNA (gDNA) from Tossa Jute (Corchorus olitorius O-4) was utilized for high-throughput Next Generation Sequencing (NGS) stages, including 454 GS FLX, Illumina/Solexa, and Solid. In excess of 50X scope (more than 100 billion of A, C, G, and Ts) of Jute genome-sequencing information were utilized for the draft get together. A few open-source and business genome get together and explanation pipelines were utilized to amass and break down the crude information. To approve the draft genome, transcriptome examination was additionally done. For information examination, diverse computational assets, running from an elite Cluster Server to Dell servers to Silicon Graphics SGI Altix-350 and 450, were utilized.
Decoding of Genome Jute Draft Sequencing
A consortium of scientists in Bangladesh has effectively decoded the jute plant draft genome sequencing. The consortium comprised of Dhaka University, Bangladesh Jute Research Institute, and programming organization Data Soft Systems Bangladesh Ltd. in a joint effort with Center for Chemical Biology, the University of Science Malaysia and the University of Hawaii at Manoa, USA. On June 16, 2010.
The unveiling of Jute Genome Sequencing in the Parliament by PM Sheikh Hasina
Bangladeshi Prime Minister Sheikh Hasina had unveiled in the parliament that Bangladeshi scientists had effectively done draft jute genome sequencing which will add to enhancing jute fiber. Bangladesh is the second nation after Malaysia among the creating countries in this sort of accomplishment.
Department of Bio-Chemistry and Molecular Biology, University of Dhaka
Dr. Maqsud Alam Visit to Bangladesh for discussion about “Nuts and Bolts” of Genome Sequence
In the background of such exchanges, Dr. Alam went to Bangladesh in March 2008. Amid his visit, he was welcomed by the Bangladesh Society for Biochemistry and Molecular Biology to give a discussion on his work on blood supplement, and this set the phase for various talks and introductions, including one introduction, which kept running for a few hours at the Department of Biochemistry and Molecular Biology on the “Nuts and Bolts” of genome sequencing. The crowd included numerous students and workforce from numerous fields of natural science and furthermore staff from eminent PC programming organization Data Soft.
Performance of Group “Swapna Jaatra”
This committed crowd shaped the principal working body, over two years previously the real project started. This group was known as the “Swapna Jaatra”, or the “Dream Journey”, a name proposed by a graduate understudy from Dhaka University taking an interest in Dr. Alam’s introduction. Additionally, in this gathering, the center group was framed with two noteworthy segments, science and figuring. Dr. Haseena Khan from the Department of Biochemistry and Molecular Biology, DU and Mr. Mahboob Zaman of Data Soft were made the two group pioneers of the two segments separately.
Discussion about “Raw Data” of Graduates of Different Departments
Through this concise communication with the biology graduates on from the Department of Biochemistry and Molecular Biology, and furthermore the Department of Genetic Engineering and Biotechnology of the University of Dhaka, Dr. Maqsudul Alam got his first extremely positive impression of the scholarly ability of the youthful people. This impression was later interpreted in the fantastic treatment of the raw information, and this would make his remark later that he has never gone over such gifted students.
Structure of DNA and Genome Sequence of Organisms
Genome projects are logical undertakings that eventually intend to decide the total genome sequence of an organism, be it an animal, a plant, a fungus, a bacterium, an Archaean, a protist or a virus, and to comment on protein-coding genes and other essential genome-encoded highlights. The genome sequence of an organism incorporates the aggregate DNA groupings of every chromosome in the life form. For a bacterium containing a solitary chromosome, a genome undertaking will plan to map the succession of that chromosome. For the human species, whose genome incorporates 22 sets of autosomes and 2 sex chromosomes, a total genome sequence will include 46 isolate chromosome groupings.
The Human Genome Project was a point of interest genome venture that is now majorly affecting examination over the life sciences, with potential for impelling various medicinal and business advancements.
Assembling of Genome
Genome gets together alludes to the way toward taking countless DNA sequence and assembling them back to make a portrayal of the first chromosomes from which the DNA originated. In a shotgun sequencing venture, all the DNA from a source, typically a solitary life form, anything from a bacterium to a mammal, is first cracked into a huge number of little pieces. These pieces are then “read” via computerized sequencing machines, which can read up to 1000 nucleotides or bases at once. (The four bases are adenine, guanine, cytosine, and thymine, spoke to as AGCT.) A genome assembly calculation works by taking every one of the pieces and adjusting them to each other and identifying all spots where two of the short successions, or peruses, cover. These covering peruses can be consolidated, and the procedure proceeds.
Difficulties in Calculation during Genome Assembly
A genome assembly is an extremely troublesome computational issue, made more troublesome on the grounds that numerous genomes contain huge quantities of indistinguishable groupings, known as repeats. These repeats can be a huge number of nucleotides long, and some happen in a great many distinctive areas, particularly in the vast genomes of plants and animals.
Making of “Golden Path”
The subsequent (draft) genome grouping is delivered by consolidating the data sequenced coting’s and after that utilizing connecting data to make scaffolds. Platforms are situated along the physical guide of the chromosomes making a “golden path”.
Initially, most vast scale DNA sequencing centers built up their own software for collecting the arrangements that they delivered. In any case, this has changed as the software has developed more mind-boggling and as the quantity of sequencing centers has expanded. A case of such assembler Short Oligonucleotide Analysis Package created by BGI for a new novo gathering of human-sized genomes, arrangement, SNP identification, resequencing, indel finding, and basic variety investigation.
Since the 1980s, molecular biologists and bioinformatics have made the requirement for DNA annotation. DNA annotation or genome annotation is the way toward distinguishing connecting biological data to groupings and especially in recognizing the areas of genes and figuring out what those genes do.
Completion of Genome Project
While sequencing a genome, there are generally locales that are hard to succession (frequent districts with exceedingly dreary DNA). Along these lines, ‘completed’ genome sequences are infrequently ever entire, and terms, for example, ‘working draft’ or ‘essentially complete’ have been utilized to all the more precisely portray the status of such genome projects. Notwithstanding when each base match of a genome succession has been resolved, there are still prone to be errors display since DNA sequencing isn’t a totally exact process. It could likewise be contended that a total genome project ought to incorporate the arrangements of mitochondria and (for plants) chloroplasts as these organelles have their own genomes.
Collection of Data for Arrangement of Genes
Usually detailed that the objective of sequencing a genome is to acquire data about the entire arrangement of genes in that specific genome grouping. The extent of a genome that encodes for genes might be little (especially in eukaryotes, for example, people, where coding DNA may represent a couple of percent of the whole arrangement). In any case, it isn’t generally conceivable (or alluring) to just sequence the coding districts independently. Additionally, as researchers see more about the part of this noncoding DNA (frequently alluded to as junk DNA), it will turn out to be more imperative to have a total genome sequence as a foundation to understanding the hereditary qualities and science of any given organism.
From numerous points of view, genome projects don’t restrict themselves to just deciding a DNA succession of a living being. Such ventures may likewise incorporate quality forecast to discover where the qualities are in a genome, and what those qualities do. There may likewise be connected undertakings to grouping ESTs or mRNAs to help discover where the qualities really are.
Awards and Achievements
He got Independence Day award from Government of Bangladesh.
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